Job Summary We are seeking a highly motivated and hands‑on Principal Scientist to join our growing team. In this role you will design, execute, and analyze phenotypic cell‑based screens central to our platform and collaborate with the broader biology team to advance our drug discovery efforts. The role is full‑time and on‑site in Montreal. Key Responsibilities Design, optimize, and execute pooled lentiviral screening workflows in primary human immune cells and relevant disease models Troubleshoot creatively and independently and proactively evaluate emerging screening technologies and methodologies; bring recommendations to scientific leadership Demonstrate strong motivation, attention to detail, critical and creative thinking, and the ability to fully integrate into a high energy start‑up environment Develop and rigorously maintain SOPs, experimental records, and reproducible protocols to support a high‑quality research environment Collaborate with the broader biology and computational teams to connect screen outputs to target validation and drug discovery decisions Support hit‑to‑lead characterization efforts as programs advance Ideal Candidate Ph.D. in a relevant discipline with 5-10 years of drug discovery experience in a pharmaceutical or biotech environment; or M.Sc. with 10-15 years of similar experience Hands‑on experience running phenotypic or functional screens in primary immune cells or cell lines, with a preference for pooled or high‑throughput formats Proven track record in developing, implementing, or applying high‑throughput genetic perturbation or functional screening approaches Demonstrated expertise in the design, production, and application of lentiviral libraries for large‑scale screening Proficiency in multi‑color flow cytometry, including panel design, instrument operation, and analysis software Strong quantitative mindset with the ability to interpret and communicate complex datasets clearly Excellent organizational and record‑keeping skills; comfortable working independently in a fast‑moving, early‑stage environment Strong problem‑solving ability and capacity to work independently as well as collaboratively #J-18808-Ljbffr